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It is a pleasure to introduce this third
issue of our Newsletter. The main news of the last three month period are (1)
the approval of the funding for the next three years by NSF, and (2) the award
of a major proposal ($1.8 million plus matching funds) to Marianthi
Ierapetritou (TB1 coordination) to promote commercialization or ERC-developed
continuous manufacturing technology. In particular, this important award, which
expands research funding for TB1, reflects also an increasing maturity of our
research program, as we increasingly focus on expanding the depth of our
scientific efforts while generating tangible, applicable technology.
During the last three months, we were
also extremely busy implementing the reorganized research plan (the new
four-thrust 21-project structure) approved after our successful effort to renew
funding from NSF. During the reorganization, which required designation of new
mentors by our member companies, communication between academic and industrial
team members experienced a hiatus, but since September frequency and quality of
communication is rapidly improving.
The focus for the upcoming IAB meeting
(Nov 30 and Dec 1, 2009), is to evaluate center progress since the last
meeting, complete the implementation of the project teams for each of the new
21 projects, and set the stage for a successful NSF site visit in March 2010.
Also important, we welcome our newest
center members, Automation Tooling Systems and Freeman Technology.
We look forward to productive discussions with
our colleagues.
Fernando J. Muzzio,
Director, ERC-SOPS
· A
manuscript was submitted to a special issue on Pharmaceutical Engineering in
Chemical Engineering Science. The manuscript is currently under review and
describes the use of NIR spectroscopy for monitoring continuous mixing in test
bed. The manuscript titled: “Real-time monitoring of drug concentration in a continuous powder
mixing process using NIR spectroscopy, was submitted in August 2009 by Vanarase,
A.U., Alcalà, M., Jerez Rozo, J.I., Muzzio, F.J., and Romañach, R.J.
· Dr. Rodolfo J Romañach from the UPRM Chemistry program spent one month
at Purdue during the summer working with Graduate Student Ryan McCann on
monitoring the density of roller compacts using NIR spectroscopy. The results
from this interaction were presented at the project D-1 and C-3 mentors meeting
held on October 5, 2009. This activity is part of the efforts of the new
Material Properties and Sensing Working Group.
The Forth Asian Particle Technology Symposium was
held in New Delhi, India in September 14-16, 2009. Dr. Fernando Muzzio, Rutgers University, and Dr. Rajesh
N. Davé, New Jersey Institute of Technology were invited speakers on the event
and presented “Overview
of National Science Foundation Engineering Research Center on Structured
Organic Particulate Systems (ERC-SOPS) for Pharmaceutical Applications,” and
“Particle Engineering for Pharmaceutical Applications,” respectively. Students Kapil Deshpande, Juan Osorio
(Rutgers University) and Lauren Beach, Maxx Capece and Daniel To (NJIT) also
presented on the event. The
Symposium had a session that provided
an overview of the Engineering Research Center for Structure Organic
Particulate System (C-SOPS) where the participants got the opportunity to get a
flavor of some of the research being carried out within the Center and met the
faculty and students of the center that participated on it. The center was presented as a US
National Science Foundation (NSF) funded Center involving Rutgers University
(lead institution), New Jersey Institute of Technology, Purdue University, and
University of Puerto Rico, Mayaguez. C-SOPS that brings together a
cross-disciplinary team of engineers and scientists as well as industry leaders
to improve the way pharmaceuticals, foods and agriculture products are
manufactured. Industrial members of the C-SOPS include all major US pharmaceutical
companies as well as over dozen equipment and software companies. C-SOPS
faculty and staff are focusing on advancing the scientific foundation for the
optimal design of SOPS with advanced functionality while developing the
methodologies for their active control and manufacturing.
Fourth Asian Particle Technology Symposium
“Innovations in
Particle Technology”
&
International
Technical Exhibition
(PARTECINDIA
2009)
Presentations
from the students included:
- Osorio, J. G.*, Mendez-Roman, R.,
Muzzio, F. J., “Optimizing Powder Flow Properties in Capsule Filling
Applications,” Forth
Asian Particle Technology Symposium, New Delhi, India, September 14-16, 2009.
APT2009/222
- Deshpande, K. V.*, Shapley, N.
C., “Particle Migration in
Concentrated Suspensions in Oscillatory Torsional Flows Between Parallel
Plates,” Forth
Asian Particle Technology Symposium, New Delhi, India, September 14-16, 2009.
APT2009/223
- To, D.*, Scicolone, J., Capece,
M., Anger, R., and Davé, R. N. “Methods for Sub-Micron Scale
Deagglomeration and Mixing of Nano-Particles,” Forth Asian Particle Technology Symposium, New
Delhi, India, September 14-16, 2009. APT2009/203
- Capece, M.*, Bhakay, A., Mujumdar,
A., Davé, R. N., “FB Processing for Creation of Engineered Particulates,” Forth Asian Particle
Technology Symposium, New Delhi, India, September 14-16, 2009.
APT2009/202
-
Beach, L.*, Ropero, J., Mujumdar, A., Alcalà, M., Romañach, R.
J., Davé, R. N., “Near-Infrared Spectroscopy for the Quantification
of Enhanced Flow Properties of Surface Modified Active Pharmaceutical
Ingredients,” Forth
Asian Particle Technology Symposium, New Delhi, India, September 14-16, 2009.
APT2009/201
Education Highlights #Top
RET 2009
RET 2009 @
NJIT: Five teachers
participated in the RET 2009 program: Marie Aloia, Richard Copp, Lori McCoy,
Ronald Neff, and Abey Tharian from Bayonne, Leonia, and Clifton High Schools. Together with her students, Marie Alloa conducted research to create gels with micro particles of API that could be dried to thin films to then deliver a uniform amount of API the same particle size. Richard Copp investigated the tribolelectric charge
resulting on nonprescription pharmaceutical ingredients because of interactions
between moving ingredient particles, and interactions between the particles and
surfaces of tubing types likely to be used in pharmaceutical processing. Lori McCoy and Ronald Neff investigated
the problem of whether or not heat can anneal defected crystal structures, and
Abey Tharian studied the effects of particle size and size distribution of both
coated and uncoated powders on their electrostatic charging and flowability.
REU 2009
REU 2009 @
NJIT:
Mentored by Daniel Lepek (a former ERC student now teaching at Cooper Union),
and graduate students Christian Beck, Laila Jallo, James Scicolone and Daniel
To; undergraduate students Richard Anger, Sonali Bhatnagar, Utsav Patel, Pooja
Raghavan, Fernando Rivas, Maxwell Wolfinger and Lin Louie Ying participated in
the REU 2009 program.
REU 2009 @ Rutgers: This summer we had 6 students on Rutgers University campus who were
mentored by ERC faculty and graduate students (see table below) from June 29th
– August 7th. So far over 30 students have participated at the
Rutgers University REU alone since 2007, of which over 70 percent have gone on
to graduate school. To date 2 out of the
3 seniors who participated in the 2009 summer REU are preparing applications to
apply to Rutgers Graduate School in the Chemical Engineering Department.
New Courses
-
Vibrational Spectroscopy for Pharmaceutical Analysis - QUIM 6007 – Special
Topics in Chemometrics and Vibrational Spectroscopy, this UPRM course relates to
Thrust D in the ERC. This graduate level course taught by ERC faculty Prof.
Rodolfo Romañach meets Tuesdays and Thursdays 5:00 – 6:15 PM and has 5 graduate
students attending. They are also developing new modules in chemometrics and
vibrational spectroscopy in this course, which they hope to use in the ERC in
the future. In addition, a laboratory session will be added for the first time
in this course. One ERC student, Jackeline I. Jerez is serving as teaching
assistant; and one ERC student: Karem Court Pinto is taking the course.
This same course was
delivered to industrial members from Pfizer Pharmaceuticals (Caguas, PR),
Bristol Myers Squibb (Pharmaceuticals, Humacao, PR), and Janssen-Ortho
Pharmaceuticals (Gurabo, PR) as a part of a PAT certification program. About 40
industrial members attended along with some ERC graduate students. The course
received very good feedback based on the evaluations.
- The
NJIT graduate course ChE 702: Modules in Nanopharmaceuticals taught
by Boris Khusid, related to T1: Material formation and characterization (Raj
Dave) was taught in Spring 2009. About 10 graduate students attended and found
the course very beneficial.
Outreach
Teresa Carvajal, professor from Purdue University
arranged a visit to a local high school for students to test out a module
developed for EPICS-ERCSOPS. Teresa and another ERC faculty Carl Wassgren led
this. Two undergraduate students
from this module also attended to talk to the high school students and teacher
about their activities of designing equipment and manufacturing
pharmaceuticals.
Industry - Education
Relations
BMS: In July 2009 San Kiang from
BMS talked to REU and RET participants associated with the ERC about how BMS is
related to the ERC research. He also gave an overview of his group and the
drugs associated with the company. In conclusion he talked about employment
opportunities at BMS.
GSK: In August 2009, 5 ERC
graduate students took a tour of the GSK facilities in Pennsylvania. ERC
Students: Xi Han (NJIT), Mohammad Abul Kalam Azad (NJIT), Christian Beck
(NJIT), Anagha Bhakay (NJIT), and Dan Braido (Rutgers) attended meeting with
Joseph Charles who gave them some exposure to drug product immediate release
dissolution experiments as it is done in industry.
 
Lauren
Beach
Research Assistant
NJCEP at NJIT
Tell us about your internship
in Spain.
I was working
with Dr. Manel Alcala (he used to be a post doc for Dr. Romanach at UPRM) at
the Universidad Autonoma de Barcelona in the Analytical Chemistry
department. I was learning multi-variate analysis with respect to near
infrared data of chemical compounds. It was an extension of some work
that I did with Manel at UPRM with Dr. Romanach. I was learning the
analysis side of NIR chemical data instead of the acquisition of data, which I
had done previously.
How long have you been a part of the ERC? Activities
in the ERC?
I have been in
the ERC since the first site visit from the NSF in December of 2005. I
have also served as a student leadership council representative since its
inception.
Why did you decide to attend graduate school?
I decided to
attend graduate school because I was interested in doing research and
development and in my undergraduate education I didn't have a real prolonged
opportunity to do that. Additionally, I wasn't sure which field I wanted
to be in, but most companies require a PhD to do work in research and
development. I also wanted to leave the door open to be in
academia.
What are your research interests?
My research
interests revolve around Pharmaceutical Development and Manufacturing. My
thesis focuses on enhancing flow properties of pharmaceutical powders, but I am
also interest in seeing how that will pertain to manufacturing operations and
other downstream processes.
What are your future plans once you finish?
I hope initially
to get a job at a larger pharmaceutical company for a few years to further my
experience level. I hope to teach, either as an adjunct or a full professor
in the future.
What is your dream job?
My dream job
would be to work for a pharmaceutical company outside the US in a smaller
developing country to help facilitate eradicating country specific diseases.
New Grants #Top
Muzzio,
F. J., “Improving Manufacturing process for Catalysts (PI),” Haldor Topsoe,
$410,000, 1/1/10-12/31/10.
Ierapetritou,
M., “Commercialization of Continuous Pharmaceutical Manufacturing Technology,”
NSF, $1.8 million, 01/01/10 - 12/31/12.
Ierapetritou,
M., “NSF Graduate Research Supplement,” 2009-2010 ($53,938).
Ierapetritou, M., “NSF REU
supplement 2009,” ($12,000).
Shapley, Nina (PI), Matthews, K. (Co-PI),
“GAANN: Graduate Fellowships in Pharmaceutical Engineering,” Department of
Education, $522,624, 9/1/09 - 8/31/12.
Shapley, Nina (PI), Matthews, K.
(Co-PI), “Developing "Green" Nanoparticles for Eliminating
Foodborne Pathogens,” Center for Advanced Food Technology, Rutgers University
$14,000, 9/1/09 - 8/31/10.
Cuitiño,
Alberto, (PI) “CDI Type II: Cyber-enabled Engineering of Pharmaceutical
Products,” NSF, $1.9Mill, 10/1/09-9/30/13.
Cuitiño,
Alberto, (Co-PI),”Process non-uniformity during high hydrostatic pressure
processing of heterogeneous foods, USDA, $469,596, 01/01/09 - 0101/12.
Cuitiño,
Alberto, (PI), “Characterization and Modeling of Interfaces in heterogeneous
Solids for Rational Formulation,” Bristol Myers Squibb, $120,000, 9/1/09 –
5/31/11.
Cuitiño,
Alberto, (PI), “Compaction physics on the performance and stability of
granular solids,” National Institute of Pharmaceutical Technology and Education
(NIPTE) – Funding agency: FDA, $46,900, 9/1/09 – 5/31/11.
Cuitiño,
Alberto, (Senior Personnel), “Commercializing of Continuous Pharmaceutical
Manufacturing Technology,” NSF, $1.8 Mill. (award processing), 01/2010 – 1/2013
“Albert Narh -
NSF-RET Site at Engineering Research Center on Structured Organic Particulate
Systems (C-SOPS),” (Narh, Lawrey, Davé, Kimmel), National Science Foundation,
EEC-0908889, $474,522, September 1, 2009 to August 31, 2012.
ERC
faculty and Co-PIs Nina Shapley and Alex Neimark: The U.S. Department of
Education has awarded a three-year Graduate Assistance in Areas of National
Need (GAANN) grant to Rutgers University to train and support doctoral students
in pharmaceutical engineering. This $698K grant provides fellowship support for
doctoral students, and equips experts in the area of pharmaceutical
engineering. Professor Yee Chiew (PI), along with Profs Alex Neimark and Nina
Shapley (co-PI's), direct this program.
Awards and Recognitions #Top
- Prof.
Ben Glasser receives the Rutgers Scholar-Teacher Award The President of Rutgers
awarded the 2009 Scholar-Teacher Award to Prof. Ben Glasser for his "innovative
interdisciplinary research in particle technology applied to pharmaceutical and
chemical processes, his development of innovative courses that transcend
traditional disciplinary barriers and encourage exploration of new areas of
research, and his deep commitment to the academic and professional development
of all students."
- Prof. Alex Neimark has been
awarded a 2009 Blaise Pascal International Chair for his work on statistical
mechanics and molecular simulation of adsorption deformation of nanoporous
materials. This is the most prestigious French award presented annually by the
State and the Region Ile-de France to five internationally acclaimed scholars
selected from all disciplines of natural and social sciences. Among past Blaise
Pascal award winners are Nobel laureates chemist Ahmed Zeweil, physicist George
Smoot, and economist Gérard Debreu. As a Blaise Pascal International Chair,
Alex Neimark will conduct research at the Ecole Nationale Supérieure de Chimie
de Paris and present ten public lectures in France during his sabbatical leave.
- 2009-10 ExxonMobil/Gilmore & Piszczek
Scholarships: The CBE Undergraduate Program at Rutgers is very grateful to have
received scholarship donations from ExxonMobil and ExxonMobil employees and CBE
Alums, Robert Gilmore and Robert Piszczek. Congratulations to the scholarship
recipients Danielle Gal, Nhan Pham and Steven Royce (Gilmore Scholarship) and
Albert Gasser and Jessica Kofsky (Piszczek Scholarship). Albert Gasser is an
undergraduate student who works in the ERC-SOPS labs.
- Arelys Rivera, an
undergraduate student in our research group has received a Pharmaceutical
Science fellowship for the 2009-2010 Academic year from Pfizer Global Research
and Development (PGRD). Arelys is currently using Near Infrared Chemical
Imaging, Raman, and near infrared spectroscopy to study the effect of shear on
the magnesium stearate bands observed in tablets and blends.
- Bo Zhou is a PhD student
working on project A4 with Dr. Rodolfo Pinal in the Purdue IPPH department recently
received an award named 2009 Graduate Student Mentor of the Summer Award by
Summer Undergraduate Research Fellowships (SURF).
-
Ecevit Bilgili,
Ph.D., Assistant Professor, NJIT- Dr.
Bilgili has recently accepted the tenure-track assistant professorship position
at NJIT Chemical, Biological, and Pharmaceutical Engineering Department. He
will continue to further his research on the production and characterization of
particulate materials and their application in a multitude of value-added
product industries including the pharmaceutical industry. Specifically, Dr.
Bilgili is interested in nanoparticle production via various technologies such
as nanomilling, solid dispersion preparation using spray drying and fluid bed
coating/granulation, drug-loaded strip (thin-film) manufacture as well as
modeling of the aforementioned technologies. Dr. Bilgili has already started
integrating his research into the NSF-ERC for Structured Organic Particulate
Systems at NJIT and is looking forward to supporting a variety of research
projects at the center.
Dr. Bilgili brings to the ERC
team an extensive experience in process modeling and process engineering based
on his postdoctoral work at PERC, University of Florida followed by his
professional experience at Merck. As part of the project A-1 Team, Dr. Bilgili
will be supporting the activities involved in the formation and stabilization
of nanoparticle suspensions for API-loaded strip formulations. His research
group will be using a stirred media mill to produce nano-particle suspensions
in a top-down fashion. He will be establishing nano-milling laboratory funded
largely from his NJIT start up funds. In addition, he will be supporting the
Commercialization efforts within the ERC.
- Ariel R. Muliadi
has been appointed as a post-doctoral research associate to work on project
B-4. He will be working with Dr. Jim Litster, Purdue University. Ariel received his PhD in Mechanical Engineering from Purdue
University in October 2009. His dissertation was on spray measurements and
modeling for tablet coating applications.
Industrial Liaison's Report #Top
New Members
The ERC family
of members has continued to grow since our last newsletter. Our newest members are Automation
Tooling Systems (ATS), which has joined at Level 2 and Freeman Technology at
Level 3.
ATS Automation
Tooling Systems Inc. provides innovative, custom designed, built and installed
manufacturing solutions to a wide range of industries including healthcare,
pharmaceuticals, computer/electronics, automotive and consumer products. ATS corporate headquarters is in
Cambridge, Onario and serves customers from 14 manufacturing facilities in
Canada, the United States, Europe, Southeast Asia and China.
Freeman Technology, based in Worcestershire,
UK is a specialist company pioneering in the measurement and
understanding of powders and their flow properties. Its flagship product, the FT4 Powder Rheometer is a
universal powder tester that combines a powder rheometer with a shear cell
capability and a compression tester.
We are very much engaged in planning
for our upcoming Industrial Advisory Board meeting to be held at Rutgers in New
Brunswick on November 30 and December 1. We hope you can join us in this first
opportunity to review our new project line-up.
New
Members
Automation Tooling Systems (ATS)
Freeman Technology
Level
1
Abbott Laboratories
Bristol Myers Squibb
Boehringer Ingelheim
Eli Lilly
Glaxo Smith Kline
Johnson & Johnson
Pepsico
Pfizer
Schering Plough
Wyeth Pharmaceuticals
Level
2
Aztrazeneca Pharmaceuticals
Camp
DEM Solutions
Gericke AG
K-Tron
Itasca
Malvern
Procter & Gamble
Sepracor Inc.
Tunnel Consulting
Level
3
Allergan
Catalent Pharma Solutions
Schenk Accurate
Level
4
Metropolitan Computing Corp
Pharmalaser
Automated Ingredient
Presentations & Publications #Top
- Portillo,
P.M, Ierapetritou, M.G., and Muzzio, F.J., “Effects of rotation rate, mixing angle,
and cohesion in two continuous powder mixers—A statistical approach,” Powder Technology, 194, 217, 2009.
- Muzzio, F. J., Keynote talk, "Using DEM
for pharmaceutical process design", DEM User meeting, Edinburgh, UK, Aug
13 2009.
- Gulak, J., Jayjock, E., Muzzio, F. J., and
Bauer, A., Mc Glynn, P., “Inversion of Andersen Cascade Impactor Data Using the
Maximum Entropy Method,” Aerosol Science and Technology, 44, 29-37 (2010).
- Llusa, M., Levin, M., Snee, R.D., Muzzio, F.
J., “Shear induced acetaminophen de-agglomeration,” Drug Development and
Industrial Pharmacy, 2009; 35 (12) 1487–1495 (2009).
- Pingali, K.C., Saranteas, K., Foroughi, R. and
Muzzio, F.J., “Practical methods for improving flow properties of active
pharmaceutical ingredients,” Drug Development and Industrial Pharmacy, 35 (12),
1460, (2009).
- Jia, Z., Davis, E., Muzzio, F. J., and
Ierapetritou, M., “Predictive Modeling for Mixing and Feeding Processes using
Kriging and Response Surface,” JPI online, DOI 10.1007/s12247-009-9070-6,
November 2009.
- Gulak, Y., Jayjock, E., Bauer, A., and Muzzio,
F. J., “Numerical calibration of the Andersen cascade impactor at different air
flow rates,” IJP /377, 45-51 (2009).
- Llusá, M.; Sturm, K.; Sudah, O.; Stamato, H.;
Goldfarb, D.J.; Ramachandruni, H.; Hammond, S.; Smith, M.R.; Muzzio, F.J.,
“Effect of High Shear Blending Protocols and Blender Parameters on the Degree
of API Agglomeration in Solid Formulations,” Industrial & Engineering
Chemistry Research,” 48, 93-101 (2009).
- Integration of Planning and
Scheduling and Consideration of Uncertainty in Process Operations. 20th
International Symposium of Process Systems Engineering (PSE), Brazil, August
2009.
- Jia,
Z., Muzzio, F. and Ierapetritou,
M.G., “Predictive Modeling for Mixing and Feeding Powder Processes using Kriging
methodology,” Accepted for Publication, Jl. Pharm. Innov. 2009.
- Saharidis,
G., and Ierapetritou, M.G., “Scheduling of Loading and Unloading of Crude oil
in a refinery with combine mixture preparation,” Ind. Eng. Chem. Res., 48, 2624, 2009.
- Yang, H., and Ierapetritou. M.G., “A Rational Design Approach
for Amino Acid Supplementation in Hepatocyte Culture,” Biotechnology and
Bioengineering, 103, 1176, 2009.
- Lima,
F.V., Jia, Z., Ierapetritou, M.G., and Georgakis, C.,“Similarities and
Differences between the Concepts of Operability and Flexibility,” Accepted for
publication, AIChE J., 2009.
- Golias,
M.M., Saharidis, G.K., Boile, M., Theofanis, S., Ierapetritou, M.G., “The berth
allocation problem: Optimizing vessel arrvial times,” Journal of Maritime Economics
and Logistics, Accepted for publication, 2009.
- Li,
Z., and Ierapetritou, M.G., “Integrated planning and scheduling in a
decomposition framework,” Chemical
Engineering Science, 64, 3585, 2009.
- Foteinou,
P., Yang, E., Saharidis, G.K., Ierapetritou, M.G., and Androulakis. I.P., “A
Mixed-Integer Optimization Framework for the Synthesis and Analysis of
Regulatory Networks,” Jl. Glob Optim, 43,
263, 2009.
- Davis, E. and Ierapetritou, M.G., “A Centroid-Based Sampling
Strategy for Kriging Global Modeling and Optimization,” AIChE J., Accepted for publication, 2009.
- Ierapetritou, M.G. and Banerjee. I., “Shape
Reconstruction Methods for Nonconvex Feasibility Analysis,” Encyclopedia of
Optimization Second Edition, 3491-3500, C.A. Floudas and P.M.
Pardalos (eds), Springer, 2009.
- Ierapetritou,
M.G. and Jia, Z., “Gasoline Blending and Distribution Scheduling: An
MILP model,” Encyclopedia of Optimization Second Edition, 1113-1127,
C.A.
Floudas and P.M. Pardalos (eds), Springer, 2009.
- Davis,
E., and Ierapetritou. M.G., “A Kriging Based Method for the Solution of
Mixed-Integer Nonlinear Programs Containing Black-Box Functions,” In press, Jl. Glob, Opt. 43, 191, 2009.
- Ierapetritou,
M.G. and Jia, Z., “Short Term Scheduling Under Uncertainty: Sensitivity
Analysis,” Encyclopedia of Optimization Second Edition, 3560-3567,
C.A.
Floudas and P.M. Pardalos (eds), Springer, 2009.
- Kimmel, H., Hirsch, L. S., Simon, L., Alexander, L. B., and Dave, R. N., “Implementing Concepts of
Pharmaceutical Engineering into High School Science Classrooms,” Chemical Engineering Education, 43 (3),
187-193, Summer 2009.
- Ropero, J., Beach, L., Alcalà, M., Rentas, R., Davé,
R. N., Romañach, R. J., “Near-infrared Spectroscopy
for the In-line Characterization of Powder Voiding. Part I: Development of the
Methodology,” Journal of Pharmaceutical Innovation, Journal of Pharmaceutical Innovation, submitted May 2009, accepted September 2009; DOI 10.1007/s12247-009-9069-z
- Davé, R. N., “Characterization of Engineered Particles and
Particulate Systems, Invitation Presentation at The Particle Characterization
Scientific Advisory Board Forum, “Beckman-Coulter, Cellular Analysis Technology
Center, 11800 S.W. 147th Avenue, Miami, Florida, Sep 25, 2009.
- Davé, R. N., “Particle Engineering for Creation of Next-generation
Materials,” Invited Seminar presented at Indian Institute of Technology,
Gandhinagar, India, September 19, 2009.
- Davé, R. N., “Theme Symposium consisting of eight talks on
Structured Particulate Composites for Pharmaceutical & Specialty Chemicals
Applications,” Asian Particle Technology-APT2009, Delhi, India, September
14-16, 2009.
- Davé, R. N., “Particle Engineering for Pharmaceutical
Applications,” (Invited Talk), Asian Particle Technology- APT2009, Delhi,
India, September 14-16, 2009.
- Beach, L.*, Ropero, J., Alcala, M., Mujumdar, A., Romañach, R.,
Davé, R. N., “Near-infrared Spectroscopy for the In-line Quantification of
Enhanced Flow Properties of Surface Modified Active Pharmaceutical
Ingredients,” Asian Particle Technology- APT2009, Delhi, India, September
14-16, 2009.
- Beck, C.*, Dalvi, S. V., and Davé, R. N., “Controlled Liquid Antisolvent Precipitation of Poorly
Water Soluble Drugs using Rapid Mixing Device, Asian Particle Technology-
APT2009, Delhi, India, September 14-16, 2009.
- Capece, M.*, Bhakay, A., Mujumdar, A., Davé, R. N., “FB Processing
for Creation of Engineered Particulates, Asian Particle Technology- APT2009,
Delhi, India, September 14-16, 2009.
- Scicolone, J., Capece, M., Anger, R., Davé, R. N., “Methods for
sub-micron scale deagglomeration and mixing of nano-particles,” Daniel To*,
Asian Particle Technology- APT2009, Delhi, India, September 14-16, 2009.
- Lepek, D., Valverde, J.M., Pfeffer, R., Castellanos, A., Davé, R.
N., “Enhanced Nanofluidization by
Alternating Electric Fields,” AIChE Journal, Submitted November 2008, Accepted
April 2009, in press, July 2009. DOI: 10.1002/aic.11954
- To, D., Yin, X., Sundaresan, S., Davé, R. N., “Investigation of
Nano-particle Aggregate Deagglomeration via the Rapid Expansion of
High-Pressure Suspensions in Carbon Dioxide Through an Orifice,” AIChE Journal,
submitted August 2008, revised version submitted January 2009, accepted
February 2009, in press, July 2009. DOI: 10.1002/aic.11887
- Zhang, Q., Yang, J., Teng, S., Dave, R. N., Zhu, L., Wang, P.,
Young, M.-W., Gogos, C. G., “In-situ, Simultaneous Milling and Coating of
Particulates with Nano-particles,” Powder
Technology, 196 (2009) 292–297. doi:10.1016/j.powtec.2009.08.011
- Dalvi, S., and Davé, R. N., “Use of Ultrasound, Polymers and
Surfactants to Control Particle Size of Griseofulvin by Antisolvent Precipitation,”
Industrial and Engineering Chemistry
Research, February 2009, accepted, June 2009, in press, July 2009, 48 (16),
pp 7581–7593, July 2009. DOI: 10.1021/ie900248f.
- Jiang, X., Trunov, M. A., Schoenitz, M., Davé, R. N., and Dreizin,
E. L., “Mechanical Alloying and Reactive Milling in a High Energy Planetary
Mill,” Journal of Alloys and Compounds,
Volume 478, Issues 1-2, 10, Pages 246-251, June 2009. doi:10.1016/j.jallcom.2008.12.021.
- Chen, Y., Jallo, L., Quintanilla, M. A. S., and Davé, R. N.,
“Characterization of Particle and Bulk Level Cohesion Reduction of Surface
Modified Fine Aluminum Powders,” Colloids
and Surfaces A: Physicochemical and Engineering Aspects, in review,
September 2009.
- Dalvi, S., and Davé, R. N., “Analysis of Nucleation Kinetics of
Poorly Water Soluble Drugs in presence of Ultrasound and Hydroxypropyl Methyl
Cellulose during Antisolvent Precipitation,” International Journal of Pharmaceutics, submitted, August 2009.
- Beach, L., Ropero, J., Mujumdar, A., Alcalà, M., Romañach, R. J.,
Davé, R. N., “Near-infrared Spectroscopy for the In-line Characterization of
Powder Voiding, Part II: Quantification of Enhanced Flow Properties of Surface
Modified Active Pharmaceutical Ingredients, Journal
of Pharmaceutical Innovation, submitted May 2009, pending revisions.
- Hylton, K., Sangwan, M., and Mitra, S., “Microscale Membrane
Extraction of Select Antibiotics,” Anal.
Chim. Acta., 653,116–120, (2009).
- Chowdhury, S. R., Chen, Y., Wang, Y., and Mitra, S., “Rapid
Nanocomposite Synthesis Using Dispersed Single Wall Carbon Nanotubes as the
Building Blocks,” J. of Matl. Sci.
44(5), 1245 (2009).
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Zhou, B., Pinal, R., and Iqbal, Z.*, “Raman Spectroscopy of Defected
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Effect of Mixer Properties and Fill Level on Granular Flow in a Four-Bladed
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Optimize Particle Breakage in a Ball Mill,” Chemical Engineering Science, 64,
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T. and Glasser, B.J., “Electrostatic charging during the flow of grains from a
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EMPOWERment Events
@ The University Level
Rutgers University:
October 12, Dr. Paul Takhistov ERC faculty from the Food Engineering
Department of Food Science, will be speaking at the New Jersey Center for
Biomaterials, Life Sciences Building Conference Room 102 at 5:00 PM. He will be presenting "Engineered
Protein and Lipid Nano-Particles for Drug Delivery Applications".
Career Panel on Careers for Women in the Biotechnology &
Pharmaceutical Industries Tuesday October 20, 2009 7:00p-9:00p BCC
Center Hall. A panel of women leaders in the life science industry will
discuss a wide range of scientific and business related options relating to the
process of drug development in the biotechnology and pharmaceutical industries.
Engineering and Computer Science Career Fair run by
MEET, SHE, and SWE. This takes place on Wednesday Oct.21st 10a-3p in
the Busch Campus Center.
Pfizer Day: “Delivering on the Promise of Pharmaceutical Innovation”
October 28, 2009 12:00p-2:00p BME Rm. 122
2009 Pharmaceutics Conference, "Innovations in Drug
Delivery Technologies", hosted by ERC faculty Dr.
Bozena B. Michniak-Kohn, PhD on Friday November 20, 2009 9:30a-4:30p in the
Life Sciences Building – New Jersey Center for Biomaterials. This conference
will bring together researchers and companies involved with drug
delivery and pharmaceutical research to share their successes and challenges in
new research techniques, therapies and devices.
CENTER EVENTS
IAB Meeting
Nov
30 - Dec 1, 2009
Rutgers University
ERC Site Visit
March
24-25, 2010
Rutgers The State University
Charanjeet Kaur
Chemical and Biochemical Engineering
Rutgers The State University of New Jersey
98 Brett Road
Piscataway, NJ 08854
Phone: 732-445-6709
Fax: 732-445-6758
E-mail: ckaur@rci.rutgers.edu
Purdue University
Teresa Lee Cadwallader
Engineering Research Center for Structured Organic
Paticulate Systems
500 Central Drive
West Lafayette, IN 47907
Phone: 765-496-3885
Fax: 765-494-3506
E-mail: tlc3764@purdue.edu
NJIT
Lynn Failla
Chemical Engineering
New Jersey Institute of Technology
University Heights
Newark, N.J. 07102
Phone: 973-596-2457
E-mail: failla@njit.edu
UPRM
Carmen V. Santiago
Chemical Engineering
University of Puerto Rico, Mayaguez Campus
P O Box 9000
Mayaguez, PR 00681
Phone: 787-832-4040 x3256
E-mail: carmenv@ece.uprm.edu
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